Membrane-less Structure

Phase separation play a pivotal role in spatial-temporal compartmentalization in cells, thereby contributing to the establishment of distinct subcellular regions. We have shown before that key factors assemble to regulate transcription, protein translation and degradation, determine neural activity and cell fate. Neurons, in particular, represents an extreme with sophisticated polarized structure and therefore require more delicate compartmentalization, trafficking, for various dynamic activities. We are thus committed to further investigating how phase separation play a role in the brain and central nervous system, specifically, in regulating circadian rhythm, brain development and learning and memory, to illustrate.